UHPLC and HPLC Products & Reviews

The ACQUITY UPLC® Evaporative Light Scattering (ELS) Detector is designed specifically for optimal UPLC®/ELS performance in a small footprint. When your analytes have poor to no UV/Vis response, or don’t ionize well by mass spectrometry, the ACQUITY UPLC ELS Detector with the ACQUITY UPLC System lets you analyze more molecules (including sugars, triglycerides, phospholipids, antibiotics, and natural products) in a single analy…

The ACQUITY UPLC H-Class PLUS Bio System delivers the benefits of UPLC's resolution, sensitivity, and throughput in a system purpose-built for the analysis of proteins, peptides, nucleic acids, and glycans.

The 2545 Quaternary Gradient Module is a four solvent, low pressure mixing gradient pump (up to 150 mL/min) that serves as a solvent delivery device for purification systems. Features: • Four solvent gradient selection • Control from MassLynx, Empower, or console allowing scale up via a familiar software interface • Interfaces to a variety of detectors and peak fraction collectors for optimum purifications • Allows UV or MS di…

UPLC Technology Extends To Two Dimensions For chromatographers who require additional capabilities to increase their speed of analysis, gain sensitivity and selectivity, and perform orthogonal separations, ACQUITY UPLC® Systems can meet these needs by controlling multiple valves and pumps for 2D separations. The resolution, sensitivity, and throughput benefits of UPLC® Technology are even more important in 2D applications. Wat…

Develop in vitro diagnostic tests with superior resolution. The Thermo Scientific™ Vanquish™ MD HPLC is the ideal chromatographic separations system for laboratories whose analyte resolution is more critical than sample throughput and batch turnaround time. The small, powerful single channel Vanquish MD HPLC meets analytical needs, as well as space and budget limitations.

The EXP® Guard Column cartridge system is rated to 15,000 psi with hand-tight replaceable cartridges. This unique design connects directly to any UHPLC column with the auto-adjusting Titanium Hybrid Ferrule and EXP® Fittings, providing repeated zero-dead-volume connections and easy adjustability between various column types. Free-Turn¨ architecture allows the user to change cartridges by hand without breaking fluid connections…

The Biotage® Selekt family of flash chromatography systems combines patented gradient development software with flexible fractionation strategies for streamlined purification.

High purity, Type B, spherical silica support. 100A pore size. 1.8um, 3um, & 5um partical sizes. Variety of stationary phases.

Silica-based columns are stable and efficient but unsuitable for alkaline analyses due to the silica matrix's weakness under high pH. InertSustain C18, with its novel surface-modified silica, overcomes this limitation. It retains Inertsil's benefits—low back pressure, superior inertness, high efficiency, consistent performance, and wide solvent compatibility—while enabling analyses over a broad pH range.

TSKgel Amide-80 and TSKgel NH2-100 HILIC columns from Tosoh Bioscience are first class columns when it comes to separations of hydrophilic compounds like peptides, carbohydrates, polar natural substances, amino acids, oligonucleotides, organic polar acids and bases, even proteins.

HPLC column

Widely considered the premium columns for analyzing biopolymers by GFC, TSKgel G2000SWXL, 5 μm columns are an excellent choice for small proteins and peptide separations.

The TSKgel Alpha-4000 column is packed with rigid, porous polymer beads which show minimal shrinkage or swelling in polar organic solvents (methanol, acetonitrile, DMSO, isopropanol, THF, and HFIP). This column is stable in a wide variety of organic solvents at concentrations up to 100%.

The TSKgel OligoDNA RP and TSKgel TMS-250 columns incorporate 5 μm or 10 μm spherical porous silica with 250Å pores to allow unhindered access by large oligonucleotides and proteins respectively.

TSKgel STAT columns were designed to increase throughput for high efficiency separations of biomolecules. The nonporous, hydrophilic base material provides superior performance at reduced analysis time.

The Biochrom 30+ Amino Acid Analyzer is trusted by hospitals, reference labs, pharmaceutical and industrial labs worldwide. It accurately detects and quantifies amino acids and their derivatives in complex samples. Applications include: detection and monitoring of in-born errors of metabolism, PKU testing, clinical analysis, proteomics, drug synthesis, infusion fluids, and quality control. The system is based on cation exc…

CHIRAL TECHNOLOGIES offers an expanded line of immobilized polysaccharide chiral stationary phases (CSPs), CHIRALPAK IA™, IB™, and IC™. These immobilized CSPs allow the use of a highly extended range of solvents and offer new separation selectivities relative to conventionally coated CSPs. All three are based on high-efficiency 5-µm diameter spherical silica (or 20-µm for scale-up to semi-preparative and preparative applicatio…

ZirChrom Separations Inc. (Anoka, MN) provides a full line of zirconia-based HPLC columns for chromatographic method development.  ZirChrom HPLC columns offer unique selectivity, exacting reproducibility, high efficiency and ultra-stability.  ZirChrom columns have proven utility over a wide range of pharmaceutical compounds.  The columns may be used at both ambient and elevated temperatures (which helps enhance LC/MS sensitivi…

A Sensitive solution for HPLC, fast-LC and CE systems High Sensitivity: 10 times to 100 times greater than conventional fluorescence and up to 100,000 times more sensitive than UV detection. Versatility: 14 interchangelable different lasers availables for any application Modularity : Adaptable to CE and HPLC systems including Fast-LC, Capillary LC and nanoLC.Selectivity: Low noise and interference molecules will be detected.…

Exceptional peak symmetry and resolution Based on next-generation ultra pure silica Outstanding pH stability Ideal first choice for new method developmentProduct detail:Hypersil GOLD columns are a new LC and LC/MS column offering unsurpassed peak shape. Based on highly pure silica, Hypersil GOLD columns provide the ultimate in symmetrical peaks, even when analyzing compounds that give notoriously poor peak shape on traditional…

The Chromaster Analytical HPLC System from Hitachi has established new limits in Performance, Ease-of-Use, and Robustness. Innovative low-pressure gradient mode, “High Frequent Mode,” and Hitachi’s proprietary real-time feedback control system greatly suppress liquid pulsation resulting in unparalleled retention time and gradient reproducibility. The Hitachi Chromaster is also available with 60 MPa maximum pressure.

CoulArray® - The Only Coulometric Array Detector for HPLC ESA's pioneering electrochemical technology has made possible the multi-sensor detector for HPLC. Measure multiple analytes simultaneously, including those that are chromatographically unresolved. Only ESA's unique coulometric array detection provides: Sensitivity to femtomole levels 3D resolution of co-eluting peaks Qualitative characterization of peaks Simpl…

The Finnigan Surveyor Plus family of HPLC instruments is specifically optimized for the most demanding HPLC and LC/MS applications. Short cycle times, high sample capacity, low flow rate performance, and patented LightPipeTM technology have been integrated into one complete system for high-throughput sample processing environments.

The Shim-pack XR-ODS, which was developed with the aim of increasing the speed attained under standard column pressure conditions, has been joined by the Shim-pack XR-ODS II, which was developed in order to facilitate high-speed, high-separation analysis for a wider range of applications, such as those involving methanol mobile phases, by using a new long column. The Shim-pack XR-ODS II is a high-separation analysis column tha…

pH Gradient Buffer Solutions - Simple method development for charge variant characterization Traditionally cation-exchange chromatography using salt gradients has been successfully used to characterize MAb charge variants. However, additional effort is often required to tailor the salt gradient method for individual charge variants. Thermo Scientific™ pH buffer solutions and kits can be used to generate highly reproducible, li…