ADME-Toxicology Products & Reviews

ARRALYZE Glass Nanowell Arrays feature precisely engineered nanowells in borosilicate glass, created with our patented LIDE technology. Each array contains up to 897 individual wells (0.4 × 0.4 × 0.225mm) with dimpled bottoms for optimal single-cell isolation and analysis.

The CellTox™ Green Cytotoxicity Assay measures changes in membrane integrity that occur as a result of cell death. The assay is intended to assess cytotoxicity in cell culture after experimental manipulation. The assay system uses a proprietry asymmetric cyanine dye that is excluded from viable cells but preferentially stains the DNA from dead cells. When the dye binds DNA released from cells, its fluorescence properties are s…

Kainic Acid is a selective agonist of kainite receptors. It is also a potent excitant and neurotoxin. Chemical Name: (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid M.Wt: 213.23 Formula: C10H15NO4 Solubility: Soluble to 25nM in water Purity: >98% Storage: Store at room temperature

The CellTiter-Glo® 3D Cell Viability Assay is a homogeneous method to determine the number of viable cells in 3D cell culture based on quantitation of the ATP present, which is a marker for the presence of metabolically active cells.   This ready-to-use reagent is based on the original CellTiter-Glo® Luminescent Cell Viability Assay chemistry and eliminates the need to combine buffer with lyophilized substrate when prepa…

SYTOX™ Green Ready Flow™ Reagent is a bright, easy-to-use nucleic acid stain that helps to distinguish dead cells from live cells in flow cytometry assays. The dye can only enter cells that have lost membrane integrity and bind to DNA, acting as a counterstain when excited at 488 nm, with an emission peak of 523 nm. The reagent can be used with both mammalian and bacterial cells, and can be used in multiplex assays.FeaturesSta…

Detects apoptotic cells in situ by the indirect TUNEL method, utilizing an anti-digoxigenin antibody that's conjugated to a Fluorescein reporter molecule

The RealTime-Glo™ MT Cell Viabiilty Assay measures viability of cells in a non-lytic, real-time live-cell format, saving time, cells and reagent costs.

Quickly and accurately identify tricyclics in serum samples with Thermo Scientific™ DRI™ Tricyclics Serum Toxicology Assays, excellent tools for emergency rooms when urine specimens are not conveniently available.

Suitable for protein quantification, suitable for cell analysis, and detection. Sufficient for ≤2,000 tests  

ViaLight® Plus BioAssay Kits are designed to provide unprecedented speed and sensitivity for cytotoxicity and cell proliferation studies. The ViaLight® Assay incorporates bioluminescent detection of cellular ATP as a measure of viability. Measurement of ATP is the most accurate, effective, and direct way of determining the number of living cells in culture. The ViaLight® Plus BioAssay is designed to deliver a high, stable lumi…

For the characterization of cell death through agarose-gel electrophoresis.PrincipleBlood or cell lysis is accomplished by incubating the sample with the special Binding/Lysis Buffer. The sample is centrifuged through a column that contains glass fiber fleece. In the Binding/Lysis Buffer, nucleic acids quickly and preferentially bind to the surface of the glass fibers. The Washing Buffer rinses away salts, proteins, and other…

Application The Cytotoxicity Detection KitPLUS (LDH) is a fast, sensitive, and simple method to quantitate cytotoxicity/cytolysis based on the measurement of LDH activity released from damaged cells using the 96-well or 384-well plate format. The kit can be used in many different in vitro cell systems when damage to the plasma membrane occurs. For example: Detection and quantification of cell-mediated cytotoxicity. Deter…

The CellTiter-Blue® Cell Viability Assay provides a homogeneous, fluorescent method for monitoring cell viability. The assay is based on the ability of living cells to convert a redox dye (resazurin) into a fluorescent end product (resorufin). Nonviable cells rapidly lose metabolic capacity and thus do not generate a fluorescent signal. The homogeneous assay procedure involves adding the single reagent directly to cells cultur…

The Guava® Caspase 3/7 and 8 Assays employ a FLICA (Fluorescent Labeled Inhibitor of Caspases) reagent that specifically identifies active caspase 3 and 7 molecules or caspase 8 molecules. Non-cytotoxic, cell permeant dyes elimiate lysis and permeabilization procedures. Each FLICA is comprised of three subunits: A caspase-specific amino acid inhibitor containing a recognition sequence for caspase 3/7 (DEVD) or caspase 8 (LETD)…

The Promega CytoTox 96® Non-Radioactive Cytotoxicity Assay is a colorimetric alternative to radioactive cytotoxicity assays. The CytoTox 96® Assay quantitatively measures lactate dehydrogenase (LDH), a stable cytosolic enzyme that is released upon cell lysis, in much the same way as [51Cr] is released in radioactive assays. Released LDH in culture supernatants is measured with a 30-minute coupled enzymatic assay that result…

Human HepatoPac™ kits are an ideal way to conduct all your DMPK, Predictive Toxicology & Mechanistic Toxicology applications. Begin dosing as early as 3 days after receiving the kit! Use our Human HepatoPac™ Triple Donor plates for the ultimate in convenience. HepatoPac™ co-cultures derived from 3 independent and highly characterized donors are provided on a single plate (8-wells from each donor).HepatoPac™ kits can be used f…

Cellecta’s 80K Single-module Human Genome-Wide CRISPR Library was designed to be small enough (~80,000 constructs) to enable convenient genome-wide “dropout viability” screens with most standard human cell modules. With 4 sgRNAs targeting each gene, all of which have been designed using the latest criteria for effective guides described by Doench, et al. and containing the Cellecta-designed HEAT sgRNA structure which we hav…

Trevigen’s CometAssay™ provides reagents and our exclusive CometSlide™ for the rapid analysis of DNA fragmentation associated with DNA damage. Features: CometSlides allow direct application of Comet LMAgarose without base layers or pretreatment. Hydrophobic barrier allows easy application of cells directly to slide, and treatment with any of several Trevigen DNA repair enzymes. Easy to use kit format.

Kit for the detection and quantification of apoptotic cell death on a single-cell level by light microscopy in immunocyto- and immunohistochemistryBenefits Sensitive: The maximum intensity of labeling (cell staining) of apoptotic cells is higher than the nick translation method. Fast: The use of fluorescein-dUTP allows analysis of the samples directly after the TUNEL reaction, but before the addition of the secondary det…

Differentiates live cells from dead cells via fluorescent labeling

The EarlyTox™ Cardiotoxicity Kit provides a fast, simple, and reliable fluorescence-based method for identifying cardiotoxic compounds in a biorelevant assay using stem-cell derived cardiomyocytes. Leveraging our proprietary masking technology with our novel calcium sensitive indicator, researchers can:• Eliminate cardiotoxic compounds and identify potential drug candidates• Measure 384 samples in minutes rather than h…

The Incucyte® AI Cell Health Analysis Software Module is an all-in-one analysis tool that segments cells and classifies them as live or dead. It allows users to perform cell health analyses without the need for fluorescent labels, generating accurate and objective data with reduced time requirements and cost. 

The In Situ beta-Galactosidase Staining Kit provides an easy and rapid method to determine transfection efficiency by indicating beta-Galactosidase activity in individual intact cells.  In situ staining of cells directly in dishes without removing or manipulating cells  Rapid detection of Ÿ-gal activity in transfected cells  Results in 24 hours  Maximum signal with low background  Deep blue staining reaction  Kit in…

The kit is designed to use with Agilent Seahorse XF Pro analyzer for easily identifying drug-induced mitochondrial toxicity, to de-risk your drug pipeline.  It provides high sensitivity and specificity, reducing false positive and false negatives.  It is applicable to screen compound libraries with a throughput of 80 compounds per plate.  Assay performance metrics Z’ of > 0.5 is achievable following our assay workflow. 

for Latex Agglutination and Latex Turbidimetry Immunoassay