Drug Delivery refers to dosage form, route of administration, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. Drug delivery is often approached via the biopharmaceutical or small molecule drug's formulation, but it may also involve medical devices or drug-device combination products. Considerations include instrumentation, software and services.
The Agilent reciprocating holder apparatus (USP Apparatus 7) is ideal for automatic dissolution testing of dosage forms requiring a change of media, smaller volume or more vigorous agitation. Typical products tested include extended release tablets, capsules, transdermals, osmotic pumps, and arterial stents.
The Agilent 400-DS apparatus 7 enables simultaneous, small-volume drug-release testing of up to 13 samples. The 400-DS is designed for testing novel dosage forms such as combination drug products. The innovative design incorporates both the dissolution apparatus and the autosampler.
The NanoDis System provides formulation scientists with accurate release profiles of APIs using conventional dissolution apparatus in an automated, compliant manner. This functionality enables analysts to uncover the best nanoparticle formulation faster and get new drug formulations to market more quickly.
The intrinsic dissolution apparatus provides the dissolution rate of a pure active pharmaceutical ingredient (API) by exposing the API to a constant surface area of dissolution medium.
The Enhancer (immersion) Cell is a PTFE cell with adjustable volume and a retaining cap to eliminate air pockets trapped against the skin or artificial membrane that provide the diffusion barrier.
NanoXact Mesoporous Silica Nanospheres - 100 nm, 5 mg/mL in ethanol
NanoXact Mesoporous Silica Nanospheres - (Dried) - 100 nm
The Distek Model 2500 RTD Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5 and 6 plus intrinsic dissolution. The extensive users, method and reporting storage capabilities are enabled by a brilliant touch screen. Patented wireless temperature sensors continuously monitor and display the in-vessel temperature for each vessel.
The Distek Model 2500 Select Bathless Dissolution System is the culmination of three generations of patented bathless technology with extremely short media heating times and dramatically smaller energy use. Unparalleled control of the instrument plus automatic storage of component serial numbers and automatic qualification reminders makes the Model 2500 Select robust and reliable enough for QC applications yet flexible enough…
Performing dissolution tests on high potency drugs with low concentrations of active pharmaceutical ingredients is difficult, if not impossible, with a standard apparatus 1 or 2 dissolution bath. Common analytical instruments are not sensitive enough to detect such low concentrations. Distek's Small Volume Conversion Kit offers the perfect solution to these common dilemmas.
The Distek Eclipse 5300 Automated Dissolution Sampler offers rapid, accurate sampling using precision syringe pumps. The elimination of valves and rotary pumps along with the optimized sample pathway increases reliability while reducing common sources of sample carryover.
Many of the main causes of OOS dissolution tests and qualification failures are related to media deaeration and dispensing. The unique compact design and optional mobile cart lets one easily move the unit from bath to bath, while the available remote dispensing nozzle allows directly filling vessels in place. The ezfill+ is compatible with most dissolution baths on the market.
The Distek sensIR 3200 combines two exclusive technologies – bathless heating and Near IR sensing to offer the most innovative disintegration tester. Bathless heating not only reduces warm-up times but eliminates the inconveniences associated with conventional water bath-based instruments. The sensIR 3200 is available in two, four or six positions in the smallest footprint of any comparably equipped model.
The Cipher dissolution control software is a Windows-based application designed and developed by Distek which can be installed locally or networked providing full access to any Distek dissolution instrument on the network. Cipher offers the flexibility to set the level of security appropriate for your laboratory and will meet 21 CFR part 11 compliance.
Innovative diamond-like carbon (DLC) coating technology overcomes the problems associated with PTFE and improves robustness.
The universal grinder for every application
