UHPLC and HPLC Products & Reviews

TSKgel Butyl-NPR hydrophobic interaction columns for analysis of antibody-drug conjugates (ADCs) and as an orthogonal method to analyze protein aggregation, oxidation and deamidations.

The TSKgel DNA-NPR weak anion exchange column is designed to analyze nucleic acids. It routinely separates plasmid isoforms, PCR products and oligonucleotides.

Inertsil ODS columns are general-purpose reversed phase C18 columns, available in 5-µm and 10-µm particle sizes. It was the first of the ODS columns from GL Sciences, introduced back in 1986. We currently recommend InertSustain C18 or Inertsil ODS-4 columns for all new method developments.

Chromolith® HighResolution: High resolution separations without ultra high pressure. The revolutionary monolithic Chromolith® HighResolution columns are made from a single rod of high-purity monolithic silica, rather than from particles. Their unique bimodal pore structure allows the chromatographic performance to be improved significantly. Speed of analysis (separations up to 9 times faster if required) Separations two…

UHPLC columns require less solvent, but they need the highest quality there is. Merck Millipore’s LiChrosolv® solvents are optimized for UHPLC instruments. They can substantially improve the performance of your separations, particularly in combination with our proven Purospher® STAR UHPLC and Chromolith® HPLC columns. LiChrosolv® Solvents for Liquid Chromatography Benefits: Gradient grade and hypergrade qualities are suita…

Count on the Waters Arc™ HPLC System for high-efficiency separations and quality data to help meet your regulatory requirements with confidence.  The Arc HPLC system allows you to easily replicate and improve the performance of existing LC methods without compromising data quality.

Along with the reliability, ruggedness, high quality, and configuration flexibility you expect from the ACQUITY™ UPLC™ PLUS Series, the Waters™ ACQUITY Premier System delivers a step change in chromatographic performance, lab efficiency, and risk control.

The Empower Chromatography Data System is Waters’ compliance-ready chromatography data software (CDS) for advanced data acquisition, processing, and reporting that simplifies the management of chromatography test results.

Porous Graphitic Carbon (PGC) particle-packed columns which offer unique physical and chromatographic advantages to silica particle packed columns including pH stability from 1 – 14, polar compound retention under reversed-phase conditions, and temperature stability up to 250 °C.

The 1515 Isocratic HPLC Pump is an isocratic pump that offers the same performance as the 1525 Binary HPLC Pump. It features and integrated, high-pressure binary pump with on-board pulse dampening and efficient mixing. Its pulse-free solvent flow with analytical to semi-preparative flow rates are well suited for high sensitivity detectors Designed for use with 2 to 4.6 mm I.D. columns in routine HPLC applications, the pump has…

Protein/Peptide Columns

LC/GC Certified vials are tested by LC/UV for residues of chemicals used in processing and packaging vials. The septa are tested by headspace GC to ensure low levels of low molecular weight polymer. These vials are suited for analyte concentration in the µg/mL concentration; typically detectors like UV and RI.

Most chromatographers have experienced problems retaining and separating polar compounds using conventional reversed-phase chromatography.  These difficult-to-analyze compounds either pass through the column unretained or, if retained at all, co-elute at the beginning of the chromatogram.  Waters AtlantisTM columns are designed for these types of challenging separations and are available in two chemistries: dC18 and HILIC sili…

The most powerful solution to the most critical need in separation science today.

The Waters Alliance 2695 Separations Module is a high performance liquid chromatographic system with a quaternary, low-pressure mixing pump and inline vacuum degassing. Flow rates from 50 uL/min to 5 mL/min can be generated for use with 2.1 mm ID columns and larger. The autosampler has a maximum capacity of 120 vials (12x32, 2-mL) with programmable temperature control from 4 to 40°C. A heated column compartment provides temper…

Making more informed decisions in less time is a universal asset in today's laboratory. Ultra Performance LC™ (UPLC™ ), a new category of separation science pioneered by Waters, will eliminate significant time and cost per sample from your analytical process—while improving the quality of your results. With UPLC technology you benefit from: more data, faster unparalleled sensitivity greater efficiency and confidence in…

Unleash the power of your laboratory's instrumentation. CORTECS® 1.6 µm and 2.7 µm solid-core columns deliver new levels of performance. CORTECS Columns are available in both reversed-phase and HILIC options, giving you the flexibility and power to develop methods for challenging separations even faster. With different particle characteristics and innovative charged surface modifications, CORTECS Columns are suitable for use…

The analysis you’ve always desired for nano- to microscale separations The ACQUITY UPLC M-Class System delivers the most robust, reliable, and highest quality nano- to microscale UPLC separations to every laboratory performing LC/MS analyses. With unprecedented usability, the ACQUITY UPLC M-Class System enables laboratories to succeed in analyzing compounds that are severely limited in amount or availability, even amid a comp…

ACQUITY UPC2 Column Technology for Chiral and Achiral Separations. ACQUITY UPC2 Trefoil™ 2.5 µm Columns are uniquely designed for the ACQUITY UPC2 System. Selectivity and speed for chiral separations Reduce method development time Based on modified polysaccharide-based stationary phases for broad-spectrum chiral selectivity. ACQUITY UPC2 Torus™ Columns simplify the method development process with four completely new…

Empower™ 3 Method Validation Manager (MVM), an option for Empower 3 Chromatography Software, allows you to perform chromatographic method validation, from protocol planning through final reporting, in one application.With Empower 3 MVM you can automatically: Manage method validation workflow in one comprehensive, automated application Clearly display the status of ongoing validation studies – enabling you to see at what…

Reimagine Released N-Glycan Analysis.

HILIC for Large Biomolecules.

Size Exclusion Columns.

Oligonucleotide Columns

Reversed-Phase Peptide Columns