pTau-181 Biomarker Assay
Advance your neurology research from discovery to the clinic by reliably detecting pTau-181 in plasma, serum, or cerebrospinal fluid (CSF).
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About Tau Protein
Tau is a microtubule-stabilizing protein primarily localized in neurons of the central nervous system but also expressed at low levels in astrocytes and oligodendrocytes. Tau consists of six isoforms in the human brain with molecular weights of 48,000 to 67,000 daltons, depending on isoform.
pTau-181 in Neuropathology
Elevated tau in CSF is a hallmark of patients with neurodegenerative disease and severe head injuries, suggesting its extracellular release during neuronal damage and its role as a biomarker with specificity for brain injury. In Alzheimer’s disease (AD) and related neurodegenerative diseases, including chronic traumatic encephalopathy, tau is abnormally phosphorylated and aggregated into bundles of filaments. Threonine 181 is one of the phosphorylation sites of human tau protein (pTau-181). pTau-181 has been found to be specifically elevated in individuals with AD pathology, even before cognitive symptoms arise or before the presence of positive Tau PET.
About the pTau-181 Assay
The Simoa® pTau-181 assay targets the proline rich region of the Tau protein which is highly conserved amongst the tau isoforms. Our ready-to-use Simoa® kits contain all the reagents necessary to run your pTau-181 assays on the HD-1/HD-X, or SR-X platforms.
