QPatch HT and QPatch HTX
The QPatch HT and QPatch HTX enable high-throughput patch clamping with 48 parallel recording sites. Automated patch clamping with the same high quality afforded by conventional patch clamping can now be applied in all phases of ion channel drug discovery, including primary screening of focused compound libraries. • Up to 7000 data points per day • Screening and compound profiling • Multi-hole and single-hole mode (QPatch HT…
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The QPatch-HT is a high-quality (GOhm seal) 48 channel APC device. It has some very advantageous features, not the least of which includes an on-board cell prep station (Qstir and Qfuge) and automated plate handling proceedure. When it is working well, it can be fantastic (e.g. I have had up to 4 months of continual screening on three different targets with little/no interuption). The down-side is that there are times when the device either underperforms and/or crashes and significant assistance from customer support is needed to get things "back to normal". Customer support is generally very good--but you do NEED it. Consumables are expensive but can be well worth the price for the quality of data for important targets/programs.
Review Date: 13 May 2011 | Sophion Bioscience
The QPatch HT and QPatch HTX enable high-throughput patch clamping with 48 parallel recording sites. Automated patch clamping with the same high quality afforded by conventional patch clamping can now be applied in all phases of ion channel drug discovery, including primary screening of focused compound libraries.
• Up to 7000 data points per day
• Screening and compound profiling
• Multi-hole and single-hole mode (QPatch HTX)
• Ligand- and voltage-gated recordings
• Eight pipette liquid handling with intelligent scheduler
• True gigaseals
• Flow channels for solution exchange
• Up to 50 liquid additions
• User-friendly experiment execution
• Unattended operation for several hours
• On-board cell preparation
• Elevator units for QPlate stacking
• Elevator units for compound plate stacking
• Cell clone screening feature
• Multiple intracellular solutions testing feature
• User friendly assay setup and quick data analysis
