Identification and optimization of the chemical, series of chemicals or bio-molecule that will interact with the target using impartial, expert opinion about the best equipment, services and the latest techniques
The human KCNA3 gene encodes the pore-forming subunit of a voltage-gated potassium channel. Kv1.3 channels expressed in lymphocytes are therapeutic targets in autoimmune diseases. Synonyms: hKv1.3 Host cell: CHO-K1, division-arrested Gene name: KCNA3 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth…
The human KCNQ1 gene encodes the pore-forming subunit of a voltage-gated potassium channel. Co-expression with minK, an auxiliary subunit, recapitulates native function in heterologous expression (CHO cells). KvLQT1/minK channels expressed in the heart are safety targets in congenital and acquired long QT syndromes. Synonyms: Kv7.1/minK Host cell: CHO-K1, division-arrested Gene name: KCNQ1/KCNE1 Mycoplasma status: Negative (M…
The human KCNQ4 gene encodes the pore-forming subunit of a voltage-gated potassium channel. KCNQ4 channels expressed in CNS neurons are therapeutic targets in epilepsy. Synonyms: Kv7.4 Host cell: CHO-K1, division-arrested Gene name: KCNQ4 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth characteris…
The KCNH2 gene encodes the pore-forming subunit of a voltage-gated potassium channel. HERG channels expressed in cardiac muscle cells are safety targets; hERG inhibition has been linked to drug induced prolongation of the QT interval and torsade de pointes (a potentially lethal cardiac arrhythmia). Synonyms: Kv11.1 Host cell: CHO-K1, division-arrested Gene name: KCNH2 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Thr…
The human SCN1A gene encodes the pore-forming subunit of voltage-gated type-1 Na+ channels. Neuronal Nav1.1 channels are therapeutic targets in seizure, pain, and stroke. Synonyms: brain type-1 sodium channel Host cell: CHO-K1 Gene name: SCN1A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth char…
The human Nav1.2 gene encodes the pore-forming subunit of voltage-gated type-2 Na+ channels. Neuronal Nav1.2 channels are therapeutic targets in seizure, pain, and stroke. Synonyms: brain type-2 sodium channel Host cell: CHO-K1 Gene name: SCN2A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth cha…
The SCN3A gene encodes the pore-forming subunit of the voltage-gated type-3 Na+ channel. Neuronal Nav1.3 channels are therapeutic targets in seizure and pain. Synonyms: brain type-3 sodium channel Host cell: CHO-K1, division-arrested Gene name: SCN3A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth…
The SCN4A gene encodes the pore-forming subunit of the voltage-gated, skeletal muscle Na+ channel. Nav1.4 is a therapeutic target for treatment of myotonia. Synonyms: Skeletal muscle sodium channel, SkM1 Host cell: CHO-K1, division-arrested Gene name: SCN4A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS…
The human Nav1.5 gene encodes the pore-forming subunit of the voltage-gated, cardiac Na+ channel. Nav1.5 is an antiarrhythmic therapeutic target. Synonyms: cardiac sodium channel Host cell: CHO-K1 Gene name: SCN5A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth characteristics: cells remain viab…
The SCN8A gene encodes the pore-forming subunit of a voltage-gated Na+ channel. Neuronal Nav1.6 channels are therapeutic targets in pain treatment. Synonyms: NaCh6, PN4 Host cell: CHO-K1, division-arrested Gene name: SCN8A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth characteristics: cells rema…
The human Nav1.7 gene encodes the pore-forming subunit of a voltage-gated Na+ channel that is expressed in sensory and sympathetic neurons. The Nav1.7 channel is a therapeutic target in pain treatment. Synonyms: PN1 Host cell: CHO-K1 Gene name: SCN9A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Grow…
Human α4/β2 Nicotinic Acetylcholine Receptor-expressing, transiently transfected cells (HEK293). Cat#: CT7023. Cryopreserved cells, 6x10E6 cells/vial. Platform validation: QPatch™ HT
BlueScreen HC is based on the fast, accurate GreenScreen HC genotoxicity assay from Gentronix Ltd. BlueScreen HC uses the same human-derived, p53-competent TK6 cells to host a patented reporter system that exploits the proper regulation of the GADD45a gene. However, in place of GFP, BlueScreen HC utilizes a luciferase from the marine copepod Gaussia princeps to generate a luminescent output. The BlueScreen luminescent assa…
The Biochrom WPA CO 8000 is a simple, reliable instrument that measures the density of cells grown in suspension by measuring OD at 600nm. It is ideal for cells grown in suspension such as yeast and bacterial cultures. Features Completely portable, this hand-held instrument has a rechargeable battery with a long life enabling it to be taken to where the cell cultures are growing. The CO 8000 can be used in incubation ca…
The VisiTech laser engine combines the tightly collimated beams from multiple lasers into a single collinear beam. This module houses up to six solid state lasers with their associated controller systems. An optional fibre input port for combining externally generated laser lines is available. The AOTF module may also be integrated with this unit to permit computer control of laser line selection, individual line intensity a…
The Thermo Scientific ABgene 384-well Diamond PCR Plate is the world's most rigid 384-well PCR plate and has specifically been developed for reliable performance on high-throughput robotic handling systems. The uniform thin-wall design has been optimized for use in PCR and QPCR applications but also offers the advantage of delivering superior resistance to warping during PCR cycling, thus reducing evaporation issues associat…
Thermo Scientific Pinpoint software is designed to simplify the transition from early-stage biomarker discovery to larger-scale, quantitative verification of putative biomarkers and general quantitative proteomics. It takes advantage of the power of Thermo Scientific TSQ triple quadrupole mass spectrometers to generate high-confidence quantitative data. Pinpoint software is in final stages of development; but for a limited t…
Continuously variable speed makes the Vortex Mixer VX-200 useful for a variety of applications, from gentle mixing to resuspending pellets. The unit has a circular orbit, rather than the elliptical orbit found on many other vortexers. This allows a vortexing motion to be achieved even at low Many speeds, a task that cannot be accomplished with eliptical orbit units. Many vortex mixers prevent excessive vibration with added wei…
Cisbio Bioassays has developed Cellul'erk, a highly accurate HTRF assay for measuring phosphorylated ERK1/2 in 96-, 384- and 1536-well formats providing for an HTS compatible assay. Features: • Simple assay protocols designed for research studies (96-well plates) for HTS (384-small vol. plates) • Cell-based functional assay • Antibody-based detection • Direct detection Applications: • Gi, Gs, or Gq coupled receptor activatio…
Efficient processing of liquid volumes up to 20 litres • Supor membrane has high flow rates and throughputs, and is ideal for solutions where low protein binding is required. Not recommended for use with some ketones. • Built-in prefilter extends filter life when viscous or particulate solutions such as serum-containing media are processed. • Upstream air vent prevents vapor lock. • Manufactured without the use of adhesives to…
Fast, final filtration and high throughputs for liquid volumes up to 150 litres • Provides higher throughputs and faster flow rates than similarly-sized competitive devices. • Ideal for solutions requiring low protein binding. • Saves money by increasing throughput with available built-in prefilter. • 100% integrity testing assures sterile filtrate. • 0.1 µm Supor membrane version ensures sterile, mycoplasma-free cell culture…
High air flow rate venting applications • Exhibits high air and liquid flow rates provided by 300 cm2 PTFE membrane. • Offers broad chemical compatibility provided by PTFE membrane and polypropylene housing. • 100% integrity tested to provide the high level of confidence you require.
Our Columbus™ Image Data Storage and Analysis system is an instrument agnostic image analysis and management platform. NEW! Signals Image Artist™ is our next-generation solution for image analysis and management.
Anagnostics' hybcell is the world's first DNA or protein microarray based on the use of cylinders instead of slides. hybcell technology is... KINETIC - by means of consecutive scans, FAST - with help of rotational sample agitation, FLEXIBLE - due to fixed starting temperatures, flexible temperature profiles and computer-controlled buffer exchange and EFFICIENT - by automated processing and electronically documenting of up to 9…
Hyborg is a fully automated device for processing and analysing hybcells (cylindrical DNA and protein microarrays). Hyborg integrates thermocycler, hybridisation station and scanner into a single device. All processing steps - from temperature profiles or exchange of liquids to multi-color scanning - are computer-controlled and documented. Hyborg's concept of totally integrated automation guarantees maximum reproducibility o…
