Drug discovery > Pre-Clinical Development Products & Reviews

The Griess Reagent System measures nitrite (NO2–), which is one of two primary stable and nonvolatile breakdown products of nitric oxide (NO). Nitric oxide is an important physiological messenger and effector molecule in many biological systems, including immunological, neuronal and cardiovascular tissues. This assay relies on a diazotization reaction that was originally described by Griess in 1879. Through the years, many mod…

The ROS-Glo™ H2O2 Assay is a homogeneous, fast and sensitive bioluminescent assay that measures the level of hydrogen peroxide (H2O2), a reactive oxygen species (ROS), directly in cell culture or in defined enzyme reactions.   This assay allows identification of conditions or test compounds, such as small molecule inhibitors or inducers, that alter ROS levels. The scalable multiwell format couples a stable luminescent si…

The CellTiter-Glo® Luminescent Cell Viability Assay(a,b) is a homogeneous method of determining the number of viable cells in culture based on quantitation of the ATP present, an indicator of metabolically active cells. The CellTiter-Glo® Assay is designed for use with multiwell formats, making it ideal for automated high-throughput screening (HTS), cell proliferation and cytotoxicity assays. The homogeneous assay procedure in…

The CellTiter-Glo® 2.0 Assay provides a homogeneous method for determining the number of viable cells in culture by measuring the amount of ATP present, which indicates the presence of metabolically active cells. The CellTiter-Glo® 2.0 Assay is based on the original CellTiter-Glo® Assay chemistry but with improved storage convenience for easy implementation. The CellTiter-Glo® 2.0 Assay is provided as a single, ready-to-use re…

The Lactate-Glo™ Assay is a bioluminescent assay for rapid, selective and sensitive detection of L-lactate in biological samples. Lactate is produced by glycolysis, a major metabolic pathway responsible for glucose homeostasis and energy production (1,2). Once considered merely a byproduct of glycolysis, lactate is now considered an important regulatory molecule of intermediate metabolism involved in cancer development, diabet…

A Fluorometric Method for Estimating the Number of Nonviable Cells Present in Multiwell Plates

A Simple, Non-Radioactive Assay to Measure Glucose Uptake Inside Cells

Digitonin can be used in cell viability and cytotoxicity assays. It is a detergent solution useful for permeabilizing cells and for creating a cytotoxicity chemistry positive control. Supplied at 20mg/ml in DMSO

The Caspase-Glo ® 3/7 Assay System is  a highly sensitive caspase activity assay for use in plate-reader assays.

The CellTiter 96® AQueous One Solution Cell Proliferation Assay is a colorimetric method for determining the number of viable cells in proliferation, cytotoxicity or chemosensitivity assays. The CellTiter 96® AQueous One Solution Reagent contains a tetrazolium compound [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt; MTS(a)] and an electron coupling reagent (phenazine ethos…

BRAND Transferpette® S pipettes offer superior performance, comfort, and value. Constructed with innovative composite materials, the Transferpette® S pipettes are lightweight and fully autoclavable.  The 4-digit display is easy to read for precise volume settings, and is always visible during pipetting. Adjustable and fixed-volume single channel pipettes from 0.1µL to 10mL, multichannels from 0.5µL to 100µL. Features:…

NEW immunoGrade™, hydroGrade™, and lipoGrade™ BRANDplates® from BrandTech Scientific feature specially treated surfaces for use in a variety of immunological assays, such as ELISA, RIA, FIA and more. Available in a full range of well shapes and colors in 96-, 384-, and 1536-well formats. 96-well BRANDplates® immunoassay microplates feature blue alphanumeric embossing for easy well identification. immunoGrade™ — High Binding Ca…

The GSH-Glo™ Glutathione Assay is a luminescence-based assay for the detection and quantification of glutathione (GSH). The assay is based on the conversion of a luciferin derivative into luciferin in the presence of glutathione, catalyzed by glutathione S-transferase (GST). The signal generated in a coupled reaction with firefly luciferase is proportional to the amount of glutathione present in the sample. Luminescence is gen…

IRDye and VRDye secondary antibodies are highly cross-adsorbed, making them suitable for multi-color detection. IRDye secondary antibodies have been optimized for use with the Odyssey® family of imaging systems and can be used on instruments with similar excitation and emission filters.

The Pearl Trilogy Small Animal Imaging System is a small animal in vivo imaging system that offers bioluminescence detection and dual-channel near-infrared fluorescent detection.

Metrohm presents Combustion IC (CIC), a fully automated system for the simultaneous determination of halogens and sulfur in widely differing matrices. With CIC, unlike with alternative methods the concentrations of the different halogens can each be shown separately. Moreover, digestion by pyrolysis is superior to offline digestion methods with regard to sample throughput and precision and correctness of results. CIC is ideal…

MultiFlo FX can dispense up to 4 independent reagents into 6- to 1536-well microplates.

Micronic 1.40ml round bottom tubes are proven to be an industry standard solution for many sample storage applications. The tubes provide an affordable way to improve your sample storage, handling and logistic processes.

The 4 different coding concepts on one Micronic 1.40ml hybrid tube enable researchers to verify information and keep identifying samples when automated or visual sample identification methods are challenging.  

The Micronic 96-4 Racks are based on ANSI/SLAS standards for storage racks and designed for Ultra Low Temperature sample storage.  

To anticipate on the trend to store samples in cryogenic temperatures, the 1.40ml tubes with external thread have a sturdy design and thick tubes wall - excellent properties for ultra-low temperature storage.

The Push Cap Decapper CP600 & CP610 can cap Micronic Push Caps (i.e. Capclusters or Capmats) on 96-format tubes with internal thread in rack.

Automated membrane protein screening, optimization, and scale-up to empower better protein crystallization research. 

mosquito crystal helps scientists to automate and streamline liquid handling workflows in protein crystallography drop setting and beyond while enhancing research quality and productivity. 

Accurate low volume (nL - µL) pipetting