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Ion Channel Cell-Based Assays

ChanTest Corporation

Functional cell-based assays provide more physiologically useful information compared to binding and non-cellular assays. ChanTest offers cell-based assays to over 90 ion channel targets for screening and profiling for both early discovery and safety liability assessment. Both replicating and division-arrested cell lines are available for most targets which have been validated on a variety of automated electrophysiology plat…

5.0/5.0
|1 Review

Human ASIC1a Channel EZCells™

ChanTest Corporation

The ASIC1a gene encodes the pore-forming subunit of a proton-gated, non-selective cation channel. ASIC1a channels expressed in neurons are therapeutic targets for treatment of pain and depression. Synonyms: Acid-sensing (proton-gated) ion channel Host cell: CHO-K1, division-arrested Gene name: ACCN2 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 ce…

0.0/5.0
|0 Reviews

Human ASIC2a Channel EZCells™

ChanTest Corporation

The ACCN1 gene encodes the pore-forming subunit of a proton-gated, non-selective cation channel. ASIC2a channels expressed in neurons are therapeutic targets for treatment of pain. Synonyms: Acid-sensing (proton-gated) ion channel Host cell: CHO-K1, division-arrested Gene name: ACCN1 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growt…

0.0/5.0
|0 Reviews

Human ASIC3 Channel EZCells™

ChanTest Corporation

The ACCN31 gene encodes the pore-forming subunit of a proton-gated, non-selective cation channel. ASIC3 channels expressed in neurons are therapeutic targets for treatment of pain. Synonyms: Acid-sensing (proton-gated) ion channel Host cell: CHO-K1, division-arrested Gene name: ACCN3 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growt…

0.0/5.0
|0 Reviews


Human Cav2.2/β3/α2δ1 Calcium Channel EZCells

ChanTest Corporation

The human CACNA1B gene encodes the pore-forming subunit of voltage-gated N-type Ca2+ channels. Co-expression with the β3 and α2δ1 auxiliary subunits recapitulates function in heterologous expression (CHO cells). Cav2.2 channels, widely distributed in neurons, are therapeutic targets in neuropathic and inflammatory pain. Synonyms: N-type calcium channel Host cell: CHO-K1, division-arrested Gene name: CACNA1B/CACNB3/CACNA2D1 My…

0.0/5.0
|0 Reviews

Human HCN4 Channel EZCells™

ChanTest Corporation

The HCN4 gene encodes the pore-forming subunit of a hyperpolarization-gated, cyclic nucleotide-sensitive, non-selective cation channel. HCN4 channels expressed in the heart contribute to the pacemaker current (Ih) and are therapeutic targets for treatment of cardiac ischemia and angina. Synonyms: hyperpolarization-activated, cyclic nucleotide-gated channel Host cell: CHO-K1, division-arrested Gene name: HCN4 Mycoplasma status…

0.0/5.0
|0 Reviews

Human Kv1.3 Potassium Channel EZCells

ChanTest Corporation

The human KCNA3 gene encodes the pore-forming subunit of a voltage-gated potassium channel. Kv1.3 channels expressed in lymphocytes are therapeutic targets in autoimmune diseases. Synonyms: hKv1.3 Host cell: CHO-K1, division-arrested Gene name: KCNA3 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth…

0.0/5.0
|0 Reviews

Human KvLQT1/minK Potassium Channel EZCells™

ChanTest Corporation

The human KCNQ1 gene encodes the pore-forming subunit of a voltage-gated potassium channel. Co-expression with minK, an auxiliary subunit, recapitulates native function in heterologous expression (CHO cells). KvLQT1/minK channels expressed in the heart are safety targets in congenital and acquired long QT syndromes. Synonyms: Kv7.1/minK Host cell: CHO-K1, division-arrested Gene name: KCNQ1/KCNE1 Mycoplasma status: Negative (M…

0.0/5.0
|0 Reviews

Human KCNQ4 Potassium Channel EZCells™

ChanTest Corporation

The human KCNQ4 gene encodes the pore-forming subunit of a voltage-gated potassium channel. KCNQ4 channels expressed in CNS neurons are therapeutic targets in epilepsy. Synonyms: Kv7.4 Host cell: CHO-K1, division-arrested Gene name: KCNQ4 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth characteris…

0.0/5.0
|0 Reviews

Human hERG Potassium Channel EZCells™

ChanTest Corporation

The KCNH2 gene encodes the pore-forming subunit of a voltage-gated potassium channel. HERG channels expressed in cardiac muscle cells are safety targets; hERG inhibition has been linked to drug induced prolongation of the QT interval and torsade de pointes (a potentially lethal cardiac arrhythmia). Synonyms: Kv11.1 Host cell: CHO-K1, division-arrested Gene name: KCNH2 Mycoplasma status: Negative (MycoAlert Kit) Packaging: Thr…

0.0/5.0
|0 Reviews

Human Nav1.1 Sodium Channel Division-Arrested Cells

ChanTest Corporation

The human SCN1A gene encodes the pore-forming subunit of voltage-gated type-1 Na+ channels. Neuronal Nav1.1 channels are therapeutic targets in seizure, pain, and stroke. Synonyms: brain type-1 sodium channel Host cell: CHO-K1 Gene name: SCN1A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth char…

0.0/5.0
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Human Nav1.2 Sodium Channel Division-Arrested Cells

ChanTest Corporation

The human Nav1.2 gene encodes the pore-forming subunit of voltage-gated type-2 Na+ channels. Neuronal Nav1.2 channels are therapeutic targets in seizure, pain, and stroke. Synonyms: brain type-2 sodium channel Host cell: CHO-K1 Gene name: SCN2A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth cha…

0.0/5.0
|0 Reviews

Human Nav1.3 Sodium Channel EZCells

ChanTest Corporation

The SCN3A gene encodes the pore-forming subunit of the voltage-gated type-3 Na+ channel. Neuronal Nav1.3 channels are therapeutic targets in seizure and pain. Synonyms: brain type-3 sodium channel Host cell: CHO-K1, division-arrested Gene name: SCN3A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth…

0.0/5.0
|0 Reviews

Human Nav1.4 Sodium Channel EZCells

ChanTest Corporation

The SCN4A gene encodes the pore-forming subunit of the voltage-gated, skeletal muscle Na+ channel. Nav1.4 is a therapeutic target for treatment of myotonia. Synonyms: Skeletal muscle sodium channel, SkM1 Host cell: CHO-K1, division-arrested Gene name: SCN4A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS…

0.0/5.0
|0 Reviews

Human Nav1.5 Sodium Channel Division-Arrested Cells

ChanTest Corporation

The human Nav1.5 gene encodes the pore-forming subunit of the voltage-gated, cardiac Na+ channel. Nav1.5 is an antiarrhythmic therapeutic target. Synonyms: cardiac sodium channel Host cell: CHO-K1 Gene name: SCN5A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth characteristics: cells remain viab…

0.0/5.0
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Human Nav1.6 Sodium Channel EZCells

ChanTest Corporation

The SCN8A gene encodes the pore-forming subunit of a voltage-gated Na+ channel. Neuronal Nav1.6 channels are therapeutic targets in pain treatment. Synonyms: NaCh6, PN4 Host cell: CHO-K1, division-arrested Gene name: SCN8A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cryopreserved irradiated cells, 2x106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Growth characteristics: cells rema…

0.0/5.0
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Human Nav1.7 Sodium Channel Division-Arrested Cells

ChanTest Corporation

The human Nav1.7 gene encodes the pore-forming subunit of a voltage-gated Na+ channel that is expressed in sensory and sympathetic neurons. The Nav1.7 channel is a therapeutic target in pain treatment. Synonyms: PN1 Host cell: CHO-K1 Gene name: SCN9A Mycoplasma status: Negative (MycoAlert Kit) Packaging: Three vials of Cyropreserved irradiated cells, 2 x 106 cells/vial (6x106 cells total) Growth media: Ham’s F12; 10% FBS Grow…

0.0/5.0
|0 Reviews


Action Potential Duration (APD) Testing on hESC-Derived Cardiomyocytes

ChanTest Corporation

Evaluate compounds in human stem cell-derived, ventricular-type cardiomyocytes. Effects on action potential parameters are evaluated in single human cardiomyocytes using patch-clamp recording Benefits: Human ion channels expressed in a native cardiac environment Detects AP Prolongation (QT risk) and EADs (Torsade trigger) Stable recordings at physiological temperature with minimal diffusion delays Cost-effective Ra…

0.0/5.0
|0 Reviews