Drug discovery > Target Discovery Products & Reviews

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Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.

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Cyto-Surf® B

Sphere Bio

Cyto-Surf® B is required to operate Cyto-Mine®. It provides the surfactant necessary to make stable biocompatible picodroplets and is fully optimized for Cyto-Mine®.

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Cyto-Cartridges®

Sphere Bio

Cyto-Cartridge® provides the core microfluidic functions used by Cyto-Mine® to implement picodroplet workflows. It is a single-use, fully disposable device to ensure zero cross-contamination between runs and maintain cell quality.

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Pico-Break™

Sphere Bio

Pico-Break™ is used to gently reduce the stability of picodroplets in order to release cellular or molecular contents into an aqueous medium for subsequent processing.

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96 VVP Volume Verified Pipetting Channel Pipetting Head

Dynamic Devices

The Lynx Series Liquid Handling Robot's new 96 VVP head with Volume Verified Pipetting (VVP) offers the first air based 96 head with verified individual volumes in each channel. VVP implements real-time liquid handling feedback through the use of in-line flow sensors that exactly measure the volume of liquid being aspirated/dispensed in the tip. The actual volumetric measurement accommodates for liquid viscosity and temperatu…

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EXP® Trap Columns

Optimize Technologies, Inc.

The patent-pending EXP® Trap Column is rated for use at 20,000+ psi (1,400+ bar). This unique design connects directly to any injection valve (with 10-32 threads) or in-line with 1/16” stainless tubing for unparalleled convenience and efficiency. The EXP® Cartridge System enables chemists to quickly remove detergents or salts which can affect the ionization process in MS work. This trapping technique can concentrate the sampl…

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EXP® Stem Trap

Optimize Technologies, Inc.

The entire EXP® Stem Trap and reusable holder are only slightly larger than a standard HPLC fitting. Its slim architecture allows it to easily fit into crowded instrument compartments or to connect directly to tightly-spaced injection ports. When tightened by hand, the EXP® Stem Trap seals to 8,700+ psi. All configurations incorporate wrench-flats to enable flawless sealing to 20,000+ psi (1,400+ bar). The unique packed floati…

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EXP® Stem Filter

Optimize Technologies, Inc.

The EXP® Stem Filter features a choice of frit porosities integrated with our patented auto-adjusting stem for repeated ZDV connections with any 10-32 port. The entire filter stem and reusable holder are only slightly larger than a standard HPLC fitting. This slim architecture allows it to easily fit into crowded instrument compartments, tightly spaced injection ports, and anywhere else you need an extra level of protection ag…

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EXP® Nano Trap

Optimize Technologies, Inc.

The EXP® Nano Trap System is designed to remove detergents or salts which can affect the ionization process in MS work rated for routine use up to 20,000 psi.The new nano-scale traps are available in two formats – EXP® Nano Trap and EXP® Nano Trap HR. Both formats are available in 10 or 20 mm lengths and in a variety of bed volumes ranging from 0.25µL - 4.0µL. The EXP® Nano Trap follows a traditional trap column format, design…

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OPTI-SOLV® Solvent Reservoir Filter

Optimize Technologies, Inc.

OPTI-SOLV® Reservoir Filters employ a unique conical design inside the filter housing to prevent air bubbles from getting trapped and disturbing your analysis. While the availability of HPLC-grade solvents diminishes the need for pre-filtering, it is still imperative that a filtration device be installed in the reservoir. Placing a filter in the reservoir is an economical way to filter particles that may result from buffer sal…

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OPTI-SOLV® Biocompatible Solvent Reservoir Filter

Optimize Technologies, Inc.

A solid PTFE body keeps OPTI-SOLV® filter at the base of the bottle where a bottom-mounted titanium frit provides unrestricted solvent access. As always, Optimize makes installation as simple as possible - no tools or fittings required and includes 5 feet of pre-installed PTFE tubing. OPTI-SOLV Reservoir Filters employ a unique conical design inside the filter housing to prevent air bubbles from getting trapped and disturbing…

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OPTI-SOLV® In-Line Hand-Tight Filter System

Optimize Technologies, Inc.

The user-friendly Hand-Tight OPTI-SOLV® In-Line Filter System is well suited for a number of applications, such as high temperature, high-pressure environments where quick changes are imperative. The unique swivel design allows frits to be changed without removing the connecting tubing. Just plumb it once and leave it. The frictional forces generated at the piston/seal interface inevitably lead to particulate shedding. Placeme…

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OPTI-SOLV® In-Line Wrench-Tight Filter

Optimize Technologies, Inc.

The user-friendly Wrench-Tight OPTI-SOLV® In-Line Filter System is well suited for a number of applications, such as high temperature, high-pressure environments where quick changes are imperative. The unique swivel design allows frits to be changed without removing the connecting tubing. Just plumb it once and leave it. The frictional forces generated at the piston/seal interface inevitably lead to particulate shedding. Place…

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OPTI-LYNX™ Quick Connect Trap Columns

Optimize Technologies, Inc.

The OPTI-LYNX™ Quick Connect Trap Columns allow you to quick-connect to any 10-32 valve/port for trapping or analytical column for pre-column filtration. With OPTI-LYNX™, accessing and changing the insert takes only a quarter turn. Replace traps, filters or change configurations in seconds, without tools. OPTI-LYNX™ traps and filters (ordered separately) come in several bed volume/ diameter/ porosity combinations, allowing you…

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Normal and Disease State Tissue

BioIVT

BioIVT’s extensive, highly characterized, normal and disease-state tissue samples are collected and prepared under strict ethical and QC policies and feature detailed clinical data as well as pathologist verification of disease tissue blocks to help ensure the accuracy of your research. Custom collections or extensive inventory are available from a diverse donor pool or any commercially available species.

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Target Sufficiency

Inotiv

Target Sufficiency® is the ability of a target system to respond to a therapeutic. It reflects the abundance and forms of the drug target protein, as well as other key system proteins that connect the target to disease phenotypes and enable response. Assessment of the target system requires an analysis platform that can simultaneously capture multiple precise protein measurements.

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ecTOF

Bruker Applied Mass Spectrometry

The ecTOF is the world’s first GC-HRMS with simultaneous acquisition of EI (Electron Ionization) and CI (Chemical Ionization) information in a single injection. While using EI as the gold-standard GC/MS ionization, the ecTOF in parallel operates a novel CI source. This way it simultaneously provides perfectly aligned accurate mass structural and molecular ion information within a single GC run.

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