ADME-Toxicology Products & Reviews

ADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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ViaLight® Plus Cell Proliferation and Cytotoxicity BioAssay Kit

Lonza Group Ltd

ViaLight® Plus BioAssay Kits are designed to provide unprecedented speed and sensitivity for cytotoxicity and cell proliferation studies. The ViaLight® Assay incorporates bioluminescent detection of cellular ATP as a measure of viability. Measurement of ATP is the most accurate, effective, and direct way of determining the number of living cells in culture. The ViaLight® Plus BioAssay is designed to deliver a high, stable lumi…

4.0/5.0
|1 Review

Apoptotic DNA-Ladder Kit

For the characterization of cell death through agarose-gel electrophoresis.PrincipleBlood or cell lysis is accomplished by incubating the sample with the special Binding/Lysis Buffer. The sample is centrifuged through a column that contains glass fiber fleece. In the Binding/Lysis Buffer, nucleic acids quickly and preferentially bind to the surface of the glass fibers. The Washing Buffer rinses away salts, proteins, and other…

4.0/5.0
|1 Review

Cytotoxicity Detection KitPLUS (LDH)

Application The Cytotoxicity Detection KitPLUS (LDH) is a fast, sensitive, and simple method to quantitate cytotoxicity/cytolysis based on the measurement of LDH activity released from damaged cells using the 96-well or 384-well plate format. The kit can be used in many different in vitro cell systems when damage to the plasma membrane occurs. For example: Detection and quantification of cell-mediated cytotoxicity. Deter…

4.0/5.0
|1 Review

Caspase 3/7 Reagent Kit (100 tests)

Merck

The Guava® Caspase 3/7 and 8 Assays employ a FLICA (Fluorescent Labeled Inhibitor of Caspases) reagent that specifically identifies active caspase 3 and 7 molecules or caspase 8 molecules. Non-cytotoxic, cell permeant dyes elimiate lysis and permeabilization procedures. Each FLICA is comprised of three subunits: A caspase-specific amino acid inhibitor containing a recognition sequence for caspase 3/7 (DEVD) or caspase 8 (LETD)…

3.9/5.0
|2 Reviews

Human HepatoPac™ Kits

Hepregen Corporation

Human HepatoPac™ kits are an ideal way to conduct all your DMPK, Predictive Toxicology & Mechanistic Toxicology applications. Begin dosing as early as 3 days after receiving the kit! Use our Human HepatoPac™ Triple Donor plates for the ultimate in convenience. HepatoPac™ co-cultures derived from 3 independent and highly characterized donors are provided on a single plate (8-wells from each donor).HepatoPac™ kits can be used f…

3.3/5.0
|1 Review

CRISPR Human Genome 80K Knockout Library (plasmid)

Cellecta

Cellecta’s 80K Single-module Human Genome-Wide CRISPR Library was designed to be small enough (~80,000 constructs) to enable convenient genome-wide “dropout viability” screens with most standard human cell modules. With 4 sgRNAs targeting each gene, all of which have been designed using the latest criteria for effective guides described by Doench, et al. and containing the Cellecta-designed HEAT sgRNA structure which we hav…

3.0/5.0
|1 Review

CometAssay™ Kit

Trevigen Inc.

Trevigen’s CometAssay™ provides reagents and our exclusive CometSlide™ for the rapid analysis of DNA fragmentation associated with DNA damage. Features: CometSlides allow direct application of Comet LMAgarose without base layers or pretreatment. Hydrophobic barrier allows easy application of cells directly to slide, and treatment with any of several Trevigen DNA repair enzymes. Easy to use kit format.

3.3/5.0
|1 Review

In Situ Cell Death Detection Kit, AP

Kit for the detection and quantification of apoptotic cell death on a single-cell level by light microscopy in immunocyto- and immunohistochemistryBenefits Sensitive: The maximum intensity of labeling (cell staining) of apoptotic cells is higher than the nick translation method. Fast: The use of fluorescein-dUTP allows analysis of the samples directly after the TUNEL reaction, but before the addition of the secondary det…

3.3/5.0
|1 Review